As Chinese hit movie No More Bets that exposes digital scammers, fraud farms and gangmasters went viral, the topic of telecom scams in Southeast Asia, especially in northern Myanmar, has once again made a splash across Chinese social media. Terrifying stories in northern Myanmar involving kidnapping and human trafficking have once again brought the long-standing, difficult problem into the public spotlight and prompted heated discussion, which has deterred Chinese tourists from visiting the country, a previous hot travel destination.

This time, we witness an unprecedented effort by the Chinese government to combat telecommunications fraud. The government of Myanmar's Wa State, which has become known as a hub for telecom fraud, recently issued an internal document demanding a strict crackdown on the criminal activity, particularly those targeting Chinese citizens, according to a notice circulating online.

Although the Global Times could not verify the authenticity of the notice, the determination of the Chinese government is apparently driving effective cross-border cooperation on cracking down telecom fraud.

The public security force of border city Pu'er, Southwest China's Yunnan Province, has joined hand with their counterpart in Myanmar to launch a crackdown campaign along the border. A total of 1,207 suspected criminals involved in fraud from northern Myanmar were successfully handed over to Chinese police, including 41 fugitives wanted online.

This is the latest major achievement in the crackdown on fraud following the previous capture of 269 suspected criminals and dismantle of 11 telecom fraud dens from northern Myanmar on September 3, CCTV News reported.

Multilateral mechanism is also at work, as China, Myanmar, Thailand and Laos have vowed to protect people from gambling fraud and related crimes through joint special operation.

Who are these people engaged in fraudulent activities? What drives them to telecommunications fraud, and how were they caught up in it? What is the truth behind popular online claim of "extract their kidneys and sell their organs?" What are the challenges faced by border police working on the frontline with the mission of persuading individuals trapped in the clutches of telecom fraud to return? The Global Times reached frontline police officers, victims, and insiders to reveal how China has ramped up its efforts to crack down on telecom fraud, a plague that has spread in the era of digital payment and harmed numerous Chinese families.

Disappearing at the border

As rampant telecom fraud news and stories in Southeast Asia swept Chinese social media in recent weeks, various industries in China launched a massive anti-fraud campaign. From anti-fraud training as the first lesson for students at the beginning of the school year, to community police officers visiting homes to convince people installing anti-fraud apps on their mobile phone, and the widespread broadcasting of anti-fraud videos on public transportation, China's determination and efforts to combat telecom fraud have reached a new peak.

Frontline police officers involved in anti-fraud work highlighted the strengthened efforts.

A police officer surnamed Lin in East China's Fujian Province - a high-risk area for telecom fraud in China - told the Global Times that the local government has been investing more resources and manpower into large-scale anti-fraud campaigns since 2019.

As the three years of the COVID-19 epidemic led to an increase in the fraudulent calls, special task forces have been established since then, Lin said.

Due to intensified efforts, 80 percent of those who went from Fujian to Southeast Asia to engage in telecom fraud have been successfully persuaded to return, Lin said. However, there are still some individuals who cannot resist the temptation of making a quick buck and go back again.

Northern Myanmar, a breeding ground for violence in telecom fraud, is seen as a gold rush destination by some jobless Chinese youngsters, as fraud gangs in northern Myanmar do not set any educational threshold and offer "high salaries," catering to the desire for quick wealth.

According to data released by the China's State Council, as of March 2022, among 10,589 illegal immigrants, 70 percent of them were engaged in telecom fraud.

Lin participated in anti-fraud and persuasion campaigns in northern Myanmar in the spring of 2021. He found that only 3-5 percent of people there could actually make big money. The majority of them dreamed of "earning a big fortune," and many of them were lured by their fellow villagers or friends.

Who exactly makes up the majority of telephone fraudsters in northern Myanmar? Du Guanglei, deputy director of the public security bureau of Xiangyang, Central China's Hubei Province, conducted a survey on criminal activities along the China-Myanmar border in 2020.

The study showed that the majority of illegal immigrants were rural residents, with the majority being males, and 56 percent of them were between the ages of 20 and 30. They generally have lower education levels, with 69 percent having only completed junior high school.

The northern region of Myanmar is typically a vacuum zone in terms of systematic and efficient government management, which provides a breeding ground for crime. Some local warlords in northern Myanmar secretly supported the telecom fraud industry and collected "protection fees" from it. They used epidemic lockdowns as an excuse to obstruct those engaged in telecom fraud from returning to China over the past three years, according to Lin.

Yang, an 18-year-old who was once deeply involved in telecom fraud, shared his painful experience in Myanmar with the Global Times. With the help of a snakehead, he crossed the border from Yunnan to Myanmar in December 2020.

Upon arrival, he discovered that the "comfortable and luxurious office environment" promised in the ads was a few shabby scattered in houses in a grassy field. As soon as he met his contact, he was taken to a dim room and forced to hand over his phone, bank cards, and ID. Subsequently, Yang had his freedom restricted by armed personnel until he signed a labor contract.

Yang recalled that those who failed to meet their targets would be dragged into a room and brutally beaten, or handcuffed and electrocuted. He often heard screams. He was not spared from this ordeal either.

In February this year, after experiencing nearly two years of nightmare in Myanmar, Yang finally saved enough money to redeem himself and regain his freedom. As soon as he left, Yang went straight to the border checkpoint in the border city of Ruili and surrendered himself to Chinese police officers.

"The past three years of the pandemic have seen the greatest efforts and the highest number of successful persuasions for returnees. There have indeed been cases of people queuing up online to voluntarily surrender and return to the country," said Lin.

"Persuasion involves reasoning with them and appealing to their emotions. For those who have been listed as fugitives by the public security organs, I advise them to return and surrender themselves, as having mitigating circumstances can reduce their punishment. We also mobilized their family members to persuade them. Some people, upon seeing their parents coming to the border crying and urging them to come back during video calls, have chosen to turn back from the wrong path," said Lin.

Paying a ransom and fleeing have become the mainstream ways to escape the scam hub, according to the veteran policeman. He said that the majority of people who return are able to find jobs and resume their normal lives. For those who are unable to find jobs for a period of time after returning, the local government will provide training and support.

Cross-border cooperation upgraded

Recently, the public security authorities have investigated and sorted out a batch of clues related to criminal activities involving Myanmar in the northern region. Over 1,100 of them were telecom fraud cases, involving a total amount of 120 million yuan ($16.37 million), media reports said.

An insider from the Yunnan border police department told the Global Times that due to the absence of an extradition treaty between China and Southeast Asian countries including Myanmar, Chinese police face difficulties in enforcing the law overseas to crack down on fraud gangs abroad. The cost of rescuing a person from criminal gangs is also high. However, the governments in the China-Myanmar border regions are currently holding meetings to negotiate the establishment of a long-term mechanism to combat telecom fraud crimes.

According to CCTV News, on August 15, the Chinese Ministry of Public Security, the Royal Thai Police, the Myanmar Police Force, and the Lao Ministry of Public Security jointly launched a special cooperative operation against gambling fraud and related crimes such as human trafficking, kidnapping, and illegal detention in Chiang Mai, Thailand.

The four parties decided to establish a comprehensive coordination center for the special operation in Chiang Mai, Thailand, and set up joint action points in areas where gambling fraud is rampant to crack down on crimes such as human trafficking, kidnapping, and detention.

The parties also expressed their determination to crack down on the criminal groups, and firm determination to protect people through concrete actions.

A journalist surnamed Zhao based in Bangkok, who has been reporting telecom fraud crime for years, told the Global Times that the crime is mainly concentrated in the Thailand-Myanmar border area, especially in areas with lax security and rampant corruption.

A small portion of the Chinese involved in telecom fraud may move on to organized crime groups involved in drug trafficking and even human trafficking. But the widely circulated online rumors about people being force to sell their organs are exaggerated, said Zhao.

Zhao emphasized that in recent years, with China's strengthened crackdown efforts, the Thai government has also attached more importance to the fight against telecom fraud.

Lin believes that as the border reopened after the pandemic, the space for cross-border cooperation in combating crime has expanded, and the breeding ground for criminals is shrinking.

"I hope that one day I will no longer receive calls from victims of telecom fraud crying for help or calls from the families of fraudsters seeking salvation for their children," Lin said.

Computer: 1, Human: 0.

That’s the score after the first match between Lee Sedol, the world’s top Go player and AlphaGo, the computer program that recently defeated the European Go champion.

AlphaGo is the creation of Google DeepMind, an artificial intelligence company based in London. The company’s program is the first to give top human players a run for their money in Go, a complex Chinese strategy game that almost makes chess look like Candy Land.

AlphaGo and Sedol will play four more matches over the next week in Seoul, South Korea. The winner will receive a $1 million prize and, perhaps more importantly, secure a place in history as either the man who triumphed over the best Go-playing machine ever created — or the first machine to surpass humankind’s players.

Over the years, readers have on occasion written to me to point out what they see as an increasing politicization of Science News. These are not accolades — more than one of those readers has contemplated ending their subscription. Some of those critics deny climate change, some oppose GMOs, others view any policy discussion in our coverage as worrisome. So, are we actually getting involved in politics?
My short answer is no. But there are many areas in which science has important things to say to citizens and policy makers. And reporting on the body of evidence that relates to societal issues falls fully within our mission, even for scientific questions with political ramifications. It’s well worth the ink to inform people about pressing problems or provide factual information in what have become hotly contested and polarizing debates.
Science can help establish what’s known, what’s not known and how scientists might find answers. That’s what Science News reports on, with the aim of giving readers not a political argument but a clear idea of where the evidence currently stands and what questions remain. Facts based on sound science can perhaps even provide a common ground for people of differing opinions to speak to each other rationally.

In the case of what researchers can say with respect to the efficacy of gun laws, it turns out that there are more questions than answers. The numbers on U.S. gun violence are clear: In 2013, the United States had many more gun-related deaths than other nations with similar standards of living. But as Meghan Rosen investigated the state of the knowledge, it became evident that now, in the United States, it’s hard to even do the science. Researchers told her that they just don’t have the data needed to answer questions about the impacts of different gun control laws.

“I thought the evidence behind well-known gun control policies would be more clear-cut,” Rosen says. But studies of background checks, waiting periods and a 1994 assault weapons ban don’t necessarily show a corresponding reduction in gun violence. Maybe such laws don’t do what lawmakers intended, but there are also confounding factors that may dilute any conclusions, Rosen reports. The 1994 ban on assault weapons, for example, stopped only sales of new weapons and didn’t apply to those already in circulation. Most disturbing to Rosen was the blocking of scientific research by Congress, which has maneuvered to stop the Centers for Disease Control and Prevention and the National Institutes of Health from doing or funding work that might advocate or promote gun control laws. That has effectively reduced research into the best ways to prevent gun violence.

The science that has been done on whether U.S. gun control laws reduce gun violence has been mixed. There aren’t a lot of straightforward answers to guide policy. But in this case, science has not had a fair chance to build the foundation for an evidence-based conversation. Without facts, it really is all political. Our aim is to find and report on those facts (or the lack of them), so that they can become part of the conversation.

A gut microbe collected from chinchilla droppings might be the first complex life form to lack even a shred of a supposedly universal organelle.

Monocercomonoides, a one-celled gut microbe collected from a pet chinchilla in Prague decades ago, apparently has no mitochondria, the organelles known as the cell’s power plants. Cataloging DNA in the microbe turns up none of the known genes for mitochondrial proteins. But stealing genetic material from bacteria — which survive without mitochondria — allowed the microbe to do without them, too, researchers report May 12 in Current Biology.
Mitochondria are tiny capsules that speckle the insides of all complex cells from pond scum to people, or so textbooks have said for decades. Some complex (or eukaryotic) cells look as if they have no mitochondria; so far, though, further searches have eventually detected mitochondrial remnants.

But Monocercomonoides appears to have completely done away with mitochondria and the genes to make them, says study coauthor Anna Karnkowska, an evolutionary biologist now at the University of British Columbia in Vancouver.

This discovery marks “the most extreme mitochondrial reduction observed,” says Vladimír Hampl of Charles University in Prague, also a coauthor of the study.

The new work also supports the idea that there really is no single core function that defines mitochondria. Although commonly described as cell powerhouses, mitochondria don’t have much to do with supplying energy for cells that live in low-oxygen or no-oxygen environments, Karnkowska says. For these anaerobic cells, mitochondria can serve as more of a building studio. One supposedly essential mitochondrial function, scientists have proposed, is assembling clusters of iron and sulfur that activate a class of widely useful cell compounds.

Bacteria and other simple (prokaryotic) cells have their own assembly systems, and they don’t need to wall off the construction of iron-sulfur clusters. The newly studied Monocercomonoides carry the genes for an assembly system that looks as if it was taken from bacteria, the researchers conclude.
Researchers discovered the lack of mitochondrial genes and the bacterial substitute while working out the DNA components that encode instructions for all the proteins in the whole organism. There were notably no signs of chaperone proteins for conveying other proteins through membranes, something mitochondria do. Nor did other signature mitochondrial proteins show up.

“Pretty amazing story,” says Roland Lill of Philipps University of Marburg in Germany, who studies the way cells use iron. The new paper doesn’t change the basic idea that complex cells need very special conditions, usually created only inside mitochondria, to build their iron-sulfur clusters. “But the beauty of biology,” he says, “is that there are always amazing exceptions to basic biological rules.”

Laser blasts might help scientists tweak Earth’s thermostat by shattering the ice crystals found in cirrus clouds.

Zapping tiny ice particles in the lab forms new, smaller bits of ice, researchers report May 20 in Science Advances. Since clouds with more numerous, smaller ice particles reflect more light, the technique could combat global warming by causing the clouds to reflect more sunlight back into space, the scientists say.

Scientists from the University of Geneva and from Karlsruhe Institute of Technology in Germany injected water drops into a chilled chamber that mimics the frigid conditions high in the atmosphere, where wispy cirrus clouds live. The water froze into spherical ice particles, which the scientists walloped with short, intense bursts of laser light.
When the laser hits an ice particle, ultrahot plasma forms at its center, producing a shock wave that breaks the particle apart and vaporizes much of the ice. The excess water vapor left in the aftermath then condenses and freezes into new, smaller ice particles.
Applying this technique to clouds is “a long, long, long way in the future,” says physicist Mary Matthews of the University of Geneva, a coauthor of the study. Current laser technology is not up to the task of cloud zapping — yet. “What we are hoping for is that the advances in laser technology, which are moving faster and faster all the time, will enable high-powered, mobile lasers,” Matthews says.

But tinkering with cirrus clouds could backfire if scientists aren’t careful, says atmospheric scientist Trude Storelvmo of Yale University. The clouds also trap heat, through the greenhouse effect, so breaking up their ice particles could actually warm the Earth. The method“could potentially work, but only if you target certain types of cirrus clouds,” she says, such as those that are very thick.

There could also be warming if fossil fuels are burned to power the laser, says David Mitchell of the Desert Research Institute in Reno, Nev. “I think it’s really interesting research, but I’m just not seeing how it’s going to make the world a cooler place.”

U.S. 191 is one of the driving options for people headed to Grand Teton or Yellowstone National Parks. But the road also cuts through prime territory for mule deer and pronghorns. And cars and large wildlife don’t usually mix well. When they do tangle, the cars end up heavily damaged, and the animals end up dead.

In an effort to reduce this conflict, the Wyoming Department of Transportation spent nearly $10 million to install two overpasses and six underpasses, along with deer-proof fencing, on sections of the highway near Daniel Junction in 2012. The sites for the passes were chosen based, in part, on the migration patterns of mule deer and pronghorns through the area.

Shortly after the installation, the animals were seen using the crossings, and vehicle collisions appeared to decline. The project was labeled a success. Now, an analysis of the project finds just how successful it has been: Car collisions with pronghorn have disappeared entirely and those with mule deer have dropped by 79 percent, Hall Sawyer of Western Ecosystems Technology Inc., and colleagues report May 16 in the Wildlife Society Bulletin.

Two digital cameras were installed at each overpass and one at each underpass to monitor wildlife using the crossings during the spring and fall migration periods in 2012 through 2015. Thousands of animals started using the pathways, and each year, more and more animals crossed the highway using these safe paths. Over the years, 40,251 mule deer and 19,290 pronghorn made their way through the passages.

Of the mule deer passing through, 79 percent used the underpasses. But among pronghorns, 92 percent took the overpasses. This confirms something that researchers had thought would be true but never really had any data to back up. They figured that ungulates such as pronghorns that live in open areas and are heavily reliant on vision to detect predators should prefer overpasses, because the structures would allow the animals to have better vision and movement. The new finding supports this, at least for pronghorns, and shows that building overpasses, which are more expensive than paths beneath highways, really is necessary for some animals.

This area of U.S. 191 was one of the worst for wildlife vehicle collisions before the crossings were built, averaging 85 per year from 2005 to 2012. By the third year after the installation, though, collisions had dropped to just 16 per year.

When the crossings were put in place, the Department of Transportation claimed that, by preventing vehicle collisions, the project would essentially pay for itself in 20 years. But this project has been so successful, the team calculates, that a crossing could pay for itself in just 4 years. And then, of course, there’s the benefit for the wildlife itself, which can now more easily and safely move through the landscape.
The team does note that Wyoming did have to make a few adjustments to the project to accommodate human behavior. The overpasses are edged with high berms to prevent animals from seeing the highway, but those berms proved tempting to ATV users and motorcyclists. Because this activity is damaging to vegetation and could reduce effectiveness of the crossings, the Bureau of Land Management had to post signs warning people away.

And when the crossings first went up, some canny hunters figured that the overpasses were good spots to find hundreds of pronghorn; hunting is now banned within 800 meters of a wildlife overpass.

Ötzi had Copper Age style.

The 5,300-year-old Tyrolean Iceman, whose body was found poking out of a glacier in the Italian Alps in 1991, incorporated hides from at least five domesticated and wild animal species into his apparel, a new genetic study finds. Comparing mitochondrial DNA extracted from nine ancient leather fragments with DNA of living animals revealed the makeup of Ötzi’s clothes and a key accessory, says a team led by paleogeneticist Niall O’Sullivan. Mitochondrial DNA typically gets passed from mothers to their offspring.
Little is known about what people wore during Ötzi’s time. The findings provide a glimpse into how ancient European populations exploited domesticated animals to make clothes and other items.

Ötzi’s coat consisted of hides from at least three goats and one sheep, the scientists report August 18 in Scientific Reports. This garment may have been periodically patched with leather from whatever animals were available, the team suggests.

Goats also provided skin for the Iceman’s leggings, the new analysis indicates.

A sheepskin loincloth and a shoelace derived from European cattle round out Ötzi’s attire made from domesticated animals.

As for wild animals, Ötzi wore a brown-bear cap and toted a quiver made from roe deer. It’s impossible to know if the ancient man attached any special meaning to brown bears, “but he may have been an opportunistic hunter or a scavenger,” says O’Sullivan, of University College Dublin and EURAC Research in Bolzano, Italy.
A 2012 analysis of proteins from fur samples taken from Ötzi’s clothing identified sheep and a goatlike animal called a chamois as sources for the Iceman’s coat. A team led by biochemist Klaus Hollemeyer of Saarland University in Saarbrücken, Germany, also pegged goats and dogs or wolves as sources of skin for Ötzi’s leggings.

Disparities between Hollemeyer’s and O’Sullivan’s studies may stem from the two groups having sampled different parts of patchwork garments. In addition, the new report used advanced techniques for extracting and analyzing ancient DNA. That enabled O’Sullivan’s team to retrieve six complete mitochondrial genomes from Ötzi’s leather belongings.

O’Sullivan’s investigation “opens a new field of potential identification procedures for mammalian species in ancient leathers and furs,” Hollemeyer says.

A roughly 4,200-year-old legging found in the Swiss Alps in 2004 also features goat hide. Mitochondrial DNA extracted from that garment came from an ancient line of European goats that has largely been replaced by a genetically distinct goat population, a team led by archaeologist Angela Schlumbaum of the University of Basel in Switzerland reported in 2010.

The Swiss legging was found with pieces of bows and arrows, woolen clothes and many other artifacts where an ice patch in a mountain pass had partly melted. No human bodies have been found there.

“Possibly, goat leather was most comfortable” as legging material, says University of Bern archaeologist Albert Hafner, a coauthor of the Swiss legging study. “Modern leather trousers often use goat as well.”

White, fierce and fluffy, snowy owls are icons of Arctic life. But some of these owls are not cool with polar winters.

Every year, part of the population flies south to North American prairies. Ornithologists thought those birds fled the Arctic in desperation, haggard and hungry. But the prairie owls are doing just fine, researchers report August 31 in The Auk: Ornithological Advances.

Over 18 winters, wild snowy owls caught and banded in Saskatchewan, Canada — one of the species’ southerly destinations­­ — were 73 percent heavier than emaciated owls in rescue shelters. Females were heavier and had more fat than males, and adults were in better condition than youngsters. But regardless of age or sex, most snowy owls that made the journey south were in relatively good health.

That means southern winters may not be such a desperate move after all. Prairies are probably just a normal wintering ground for some of the Arctic snowy owl population, the researchers say. Snowbirds, indeed.

Philae has been found, nestled in a shadowy crevice on comet 67P/Churyumov-Gerasimenko. The comet lander, lost since its tumultuous touchdown on the comet on November 12, 2014, turned up in images taken by the Rosetta orbiter on September 2.

Philae is on its side with one leg sticking out into sunlight. Its cockeyed posture probably made it difficult for Philae to reliably get in touch with Rosetta, explaining why scientists had trouble reestablishing communication. The discovery came about a month before the end of the Rosetta mission; the orbiter was scheduled to land on the comet on September 30and then shut down.

Philae spent just a few days transmitting data from the comet’s surface (SN: 8/22/15, p. 13). It had a rough landing, bouncing twice before stopping. Sitting in the shadow of a cliff, Philae was unable to use solar power to recharge its battery. Rosetta picked up intermittent communication in June and July 2015. Since January, temperatures on the comet have been too chilly for Philae’s electronics; scientists stopped listening for radio signals in July.

Qian Chen, 30
Materials scientist
University of Illinois

The SN 10
In a darkened room, bathed in the glow of green light, materials scientist Qian Chen watches gold nanorods dance. They wiggle across a computer screen displaying real-time video from a gigantic microscope — a tall, beige tube about as wide as a telephone pole.

Chen has observed these and other minuscule specks of matter swimming, bumping into one another and sometimes organizing into orderly structures, just like molecules in cells do. By pioneering the design of new biologically inspired materials, she’s exploring what it means to be “alive.” Next, Chen wants to get an up-close and personal view of cellular molecules themselves: the nimble, multitasking proteins that work day and night to keep living organisms running.

At age 30, Chen is already racking up high-profile publications and turning some far-out ideas into reality. Her ultimate goal: To mimic the machinery that living cells have already perfected. To create life, or something like it, out of nonliving materials.

“If you can see it, you can start to understand it,” Chen said when I visited her lab at the University of Illinois at Urbana-Champaign earlier this year. “And if you understand it, you can start to control it.”

Chen didn’t always want to be a scientist. Growing up in China, she imagined one day becoming a writer. In middle school, she wrote an award-winning story about a girl who figures out how to repair the ozone layer. “My idea was to get some material that can be stretched, like the skin of the balloon,” Chen says.
Her interest in inventing new and unusual materials took off years later, in the United States. After graduating from college in China in 2007 — Chen was the first in her family to do so — she headed to Illinois to work with materials scientist Steve Granick.

From the start, Chen stood out. “She made hard things look easy,” says Granick, now at the Ulsan National Institute of Science and Technology in South Korea. He recalls one experiment in particular, when Chen performed a feat some scientists thought impossible: She got thousands of tiny beads to form an open and orderly two-dimensional structure — all by themselves.

Chen had been studying colloidal particles, microscopic specks roughly a micrometer in size. People normally think of these particles as a component of paint, not all that interesting.

But Chen had the idea to cover the particles with a kind of sticky coating that acted something like Velcro. When the particles bumped into one another, they stuck together. At first, “It looked like a mess, like a failed experiment,” says Granick. “Most graduate students would have just chalked it up to a mistake and gone home.”

After a day of knocking around in solution, sticking together and tearing apart, the particles finally settled into something stable. The special coating and the way Chen applied it (capping the top and bottom of each particle) led to a “kagome lattice,” something sort of like a honeycomb. Never before had scientists coaxed colloidal particles into such an open, porous framework. Usually, the particles pack together more tightly, like apples stacked on the shelf at a grocery store, Chen says.
That work led in 2011 to a publication in Nature: “Directed self-assembly of a colloidal kagome lattice.” A week earlier, Chen and Granick had published a different paper in Science, “Supracolloidal reaction kinetics of Janus spheres,” about particles that self-assemble into a twisting chain, or helix. At the time, Chen was 24.

“Her work is at the leading edge,” says Penn State chemist Christine Keating. “She’s so full of enthusiasm for science, and energy and creative ideas.”

Exactly how such particles might one day be used is still anybody’s guess. Some researchers envision self-assembling materials building smart water filters or adaptable solar panels that change shape in response to the sun. But the full range of possibilities is hard to fathom. Chen is “trying to invent the rules of the game,” Granick says. “She’s laying the groundwork for future technologies.”

Her next big focus will take her field from self-assembly 101 to the master class level, by mimicking how biological molecules behave. But first she has to see them in action.

Into the cell
In 2012, Chen traveled west to the University of California, Berkeley to work with National Medal of Science winner Paul Alivisatos on a new microscopy technique.

Scientists today can view the details of proteins and DNA close up under a microscope, but the results are typically still-life images, frozen in time. It’s harder to get action shots of proteins morphing in their natural, fluid world. That view could unveil what roles different protein parts play.

Even a technique that won its developers a Nobel Prize in 2014 (SN: 11/2/14, p. 15) — it relies on fluorescent molecules to illuminate a cell’s moving parts — can’t always reveal the intricacies of proteins, Chen says. They’re just glowing dots under the microscope. Imagine, for example, looking at a dump truck from an airplane window. You can’t see how the truck actually works, how the pistons help lift the bed and the hinges open the tailgate.

“I use this as inspiration,” Chen says, grabbing her laptop and starting up a video that may well be the fantasy of anyone exploring biology’s secret world. The computer animation shows molecules whizzing and whirling deep inside a cell. Gray-green blobs snap together in long chains and proteins haul giant, gelatinous bags along skinny tracks. No one yet has gotten a view as clear as this hypothetical one, but a technique Chen is now helping to develop at Illinois could change that.

It’s called liquid-phase transmission electron microscopy, and it’s a slick twist on an old method. In standard TEM, researchers create subnanometer-scale images by shooting an electron beam through samples placed in a vacuum. But samples have to be solid — still as stone — because liquids would evaporate.

By sandwiching beads of liquid between thin sheets of graphene, though, Chen gets around the problem. It’s like putting droplets of water in a plastic baggie. The liquid doesn’t dry up, so researchers can observe the particles inside jittering around. Chen has used the technique to see gold nanorods assembling tip-to-tip and DNA-linked nanocrystals moving and rotating in 3-D. Now, she may be on the verge of a big advance.

With liquid-phase microscopy, Chen is attempting to see cellular machinery with a clarity no scientist has achieved before. She is cautious about revealing too many details. But if Chen succeeds, she may be on her way to cracking the code that links biological structure to function — figuring out the parts of a protein, the pistons and hinges, that let it do its specific job. Knowing the structural building blocks of life, she says, will help scientists create them — and everything they can do — out of artificial materials.

“We’re not there yet,” Chen says, “but that’s the big dream.”